Experimental Oral Carcinogenesis

Osteopontin and oral carcinogenesis

down-regulation of osteopontin and breast tumour progression in vivo is highly interesting [1]. Recent studies indicate a close association between not only breast cancer and osteopontin but other systemic malignancies as well. Studies over the past few years have especially shown a strong relationship between osteopontin expression and oral carcinogenesis. For instance, Devoll et al. in a rece...

HPV infection and oral carcinogenesis.

Innate Immunity and Oral Carcinogenesis

Oral cancer is initiated from stem cells of the basal layer of the epithelium that have acquired genetic alterations [2-5]. Accumulation of genetic alterations and environmental factors drive the development of tumors to highly malignant lesions, a process involving not only tumor cells but also many other non-neoplastic cells, particularly infiltrating immune cells, in the tumor microenvironme...

Oxidative stress and experimental carcinogenesis.

The focus of this review is to provide state-of-the-art knowledge on the involvement of oxygen free radicals (OFR) in carcinogenesis with a particular reference to skin model system as the process of cancer development is best understood in this organ. However, a brief description of the role of OFR in other organs is also provided. The term OFR refers to forms of oxygen exhibiting high reactiv...

Experimental bladder carcinogenesis-rodent models.

Several rodent models of bladder cancer development have been established. The aim of this review article is to provide a critical assessment of different animal models available for the study of bladder carcinogenesis, its chemoprevention and therapy. All, except for transgenic and knockout animals, require 8-12 months experimental periods in order to generate a high yield of neoplasias. Spont...